Why Does It Work?

Simple, it's based on science.

Dr. Vitali's formula draws inspiration from modern neuroscientific research that has demonstrated how our neurons work and what they need to function at their best.

Each ingredient in the Dr. Vitali formula is designed, in its nature and dosage, to help and improve our natural cognitive processes that give us the energy, concentration and efficiency we need throughout our day.

- Caffeine Anhydrous is the dehydrated form of common caffeine. Neuroscientific research has shown that this natural substance is capable of blocking adenosine receptors (which mediates sleepiness), thereby attenuating the effects of sleepiness on arousal, alertness and attention, as well as influencing the release of excitatory neurotransmitters such as dopamine and norepinephrine.

(Urry, E., Landolt, HP. (2014) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_274 )

Fiani B, Zhu L, Musch BL, Briceno S, Andel R, Sadeq N, Ansari AZ. The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function. Cureus. 2021 May 14;13(5):e15032. DOI: 10.7759/cureus.15032

- L-Tyrosine and L-Phenylalanine are the l-enantiomers of the amino acids tyrosine and phenylalanine. They are the precursors from which the catecholamines Dopamine, Noradrenaline and Adrenaline are synthesized. Dopamine plays a fundamental role in motivation, in processes of cognitive control and cognitive efficiency; Noradrenaline and Adrenaline are excitatory neurohormones and prepare the body for action, as well as being involved in various cognitive processes such as attention, alertness, motivation and memory.

Cools R, Froböse M, Aarts E, Hofmans L. Dopamine and the motivation of cognitive control. Handb Clin Neurol. 2019;163:123-143. doi: https://doi.org/10.1016/B978-0-12-804281-6.00007-0

Berke, JD What does dopamine mean?. Nat Neurosci 21, 787–793 (2018). https://doi.org/10.1038/s41593-018-0152-y

Journal of Cardiovascular Development and Disease. Part and Parcel of the Cardiac Autonomic Nerve System: Unraveling Its Cellular Building Blocks during Development Anna MD Végh et al., 2016. DOI: 10.3390/jcdd3030028 . all rights reserved.

Stanford, SC (2020). Norepinephrine and Epinephrine: Introduction. In eLS, John Wiley & Sons, Ltd (Ed.). https://doi.org/10.1002/9780470015902.a0000271.pub4

Imam-Fulani A, Owoyele BV. Effect Of Caffeine and Adrenaline on Memory and Anxiety in Male Wistar Rats. Niger J Physiol Sci. 2022 Jun 30;37(1):69-76. https://doi.org/10.54548/njps.v37i1.9

- Pyridoxine hydrochloride (Vitamin B6), Folic acid (Vitamin B9), and Cyanocobalamin (Vitamin B12) are important cofactors in numerous enzymatic reactions in our body, especially in the metabolism of sugars and lipids, but these 3 in particular play a fundamental role in the central nervous system, especially in the synthesis of neurotransmitters such as dopamine, norepinephrine and serotonin.

C. Gonçalves, G.-V. Portari, The B-complex vitamins related to energy metabolism and their role in exercise performance: A narrative review, Science & Sports, Volume 36, Issue 6, 2021, Pages 433-440, https://doi.org/10.1016/j.scispo.2020.11.007

Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68. https://doi.org/10.3390/nu8020068

Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020 Jan;26(1):5-13.https://doi.org/10.1111/cns.13207